FBN2 and DPYSL5

		FBN2	DPYSL5
Description		fibrillin 2	dihydropyrimidinase like 5
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Cytosol Dendrite Neuronal Cell Body
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Dihydropyrimidinase Activity Protein Binding Microtubule Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	CRMPs in Sema3A signaling
Drugs		Calcium Citrate Calcium Phosphate
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)	Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Obesity-related traits ( 23251661) Reflection (response to stress) ( 30886212) Urate levels ( 31578528) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		22 interacting genes: CMBL CSF2 DPYSL5 DUSP5 ELN FBN1 FDPS ITGA2 LTBP1 MATN2 MFAP2 MFAP5 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SMAD2 SNRPB TRIM24 UBE2B	9 interacting genes: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FBN2 FES HSPA5
Entrez ID		2201	56896
HPRD ID		00416	10522
Ensembl ID		ENSG00000138829	ENSG00000157851
Uniprot IDs		P35556	Q9BPU6
PDB IDs			4B90 4B91 4B92
Enriched GO Terms of Interacting Partners?
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