EYA3 and SIX2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EYA3	SIX2
Description		EYA transcriptional coactivator and phosphatase 3	SIX homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Factor Binding Protein-containing Complex Binding
	Biological Process	Double-strand Break Repair Multicellular Organism Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)	Blood sugar levels ( 29403010) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Retinal arteriole-to-venule ratio ( 31597446)
Interacting Genes		7 interacting genes: CRK DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17	6 interacting genes: APP CDKN2A EYA1 EYA3 TLE1 TLE5
Entrez ID		2140	10736
HPRD ID		09042	05408
Ensembl ID		ENSG00000158161	ENSG00000170577
Uniprot IDs		Q99504	Q8TBA2 Q9NPC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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