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SIX2
Description
SIX homeobox 2
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Transcription Factor Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Transcription Factor Binding
Protein-containing Complex Binding
Biological Process
Kidney Development
Chondrocyte Differentiation
Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Protein Import Into Nucleus
Mesodermal Cell Fate Specification
Cell Proliferation
Anatomical Structure Morphogenesis
Anterior/posterior Axis Specification
Cell Migration
Regulation Of Ossification
Regulation Of Chondrocyte Differentiation
Middle Ear Morphogenesis
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Anatomical Structure Development
Nephron Development
Nephron Morphogenesis
Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis
Condensed Mesenchymal Cell Proliferation
Mesenchymal Cell Differentiation Involved In Kidney Development
Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Mesenchymal Stem Cell Proliferation
Positive Regulation Of Chondrocyte Proliferation
Pathways
Drugs
Diseases
GWAS
Blood sugar levels (
29403010
)
Fasting blood glucose (
29621232
)
Fasting plasma glucose (
25187374
)
Glycated hemoglobin levels (
29170429
)
Hemoglobin A1c levels (
29403010
)
Lung cancer (
28604730
)
Metabolite levels (
21909109
)
Retinal arteriole-to-venule ratio (
31597446
)
Interacting Genes
6 interacting genes:
APP
CDKN2A
EYA1
EYA3
TLE1
TLE5
Entrez ID
10736
HPRD ID
05408
Ensembl ID
ENSG00000170577
Uniprot IDs
Q8TBA2
Q9NPC8
PDB IDs
Enriched GO Terms of Interacting Partners
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