EYA2 and SIX4

Number of citations of the paper that reports this interaction (PubMedID 10490620)
89

Data Source:
BioGRID (proximity labelling technology, two hybrid)
HPRD (in vitro)

		EYA2	SIX4
Description		EYA transcriptional coactivator and phosphatase 2	SIX homeobox 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
	Biological Process	DNA Repair Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Skeletal Muscle Tissue Development Regulation Of Synaptic Growth At Neuromuscular Junction Male Gonad Development Anatomical Structure Morphogenesis Male Sex Determination Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Sarcomere Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Male Sex Differentiation Thymus Development Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Skeletal Muscle Fiber Differentiation Negative Regulation Of Satellite Cell Differentiation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Allergic rhinitis ( 31361310) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Lung function (FVC) ( 30061609 30804560) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Height ( 31562340)
Interacting Genes		9 interacting genes: AATK DMRTB1 GNAI2 GNAZ LOX RBPMS ROR2 SIX1 SIX4	2 interacting genes: EYA2 EYA3
Entrez ID		2139	51804
HPRD ID		09041	06960
Ensembl ID		ENSG00000064655	ENSG00000100625
Uniprot IDs		E7ETN2 O00167	Q9UIU6
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
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