EYA2 and GNAZ

Number of citations of the paper that reports this interaction (PubMedID 10906137)
16

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vivo, two hybrid, in vitro)

		EYA2	GNAZ
Description		EYA transcriptional coactivator and phosphatase 2	G protein subunit alpha z
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	DNA Repair Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PLC beta mediated events PLC beta mediated events G-protein activation G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Allergic rhinitis ( 31361310) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Lung function (FVC) ( 30061609 30804560) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951)
Interacting Genes		9 interacting genes: AATK DMRTB1 GNAI2 GNAZ LOX RBPMS ROR2 SIX1 SIX4	16 interacting genes: ADORA1 APP DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7
Entrez ID		2139	2781
HPRD ID		09041	00746
Ensembl ID		ENSG00000064655	ENSG00000128266
Uniprot IDs		E7ETN2 O00167	P19086 Q8IY73
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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