EYA1 and NDUFB9

		EYA1	NDUFB9
Description		EYA transcriptional coactivator and phosphatase 1	NADH:ubiquinone oxidoreductase subunit B9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body Protein-DNA Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Pattern Specification Process Mesodermal Cell Fate Specification Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Striated Muscle Tissue Development Histone Dephosphorylation Protein Sumoylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Aorta Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Anatomical Structure Development Positive Regulation Of Epithelial Cell Proliferation Pharyngeal System Development Otic Vesicle Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Mitochondrial Electron Transport, NADH To Ubiquinone Sensory Perception Of Sound Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases		Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Adolescent idiopathic scoliosis ( 30395268) Chin dimples ( 27182965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Longevity (85 years and older) ( 24688116) Paneth cell defects in Crohn's disease ( 28352666) Sleep-related phenotypes ( 17903308) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		9 interacting genes: DACH1 GNAI2 GNAZ GSK3B H2AX NDUFB9 SIX1 SIX2 SIX3	19 interacting genes: DRC7 ELP1 EYA1 FEZ1 GDF9 HAP1 IMMT MAGEA11 MEF2A OR2D2 PRDM14 PRPF31 PSMB9 RAD54B RBBP6 SH3GL3 TNIP2 UBC XRN1
Entrez ID		2138	4715
HPRD ID		03388	03264
Ensembl ID		ENSG00000104313	ENSG00000147684
Uniprot IDs		A0A024R813 A0A2R8Y6K4 A6NCB9 B3KXR1 F8WB53 Q0P517 Q99502	E9PH64 Q9Y6M9
PDB IDs			5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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