EPHB2 and GRIN1

Number of citations of the paper that reports this interaction (PubMedID 11754835)
90

Data Source:
HPRD (in vitro)

		EPHB2	GRIN1
Description		EPH receptor B2	glutamate ionotropic receptor NMDA type subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Postsynapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cell Cytoplasm Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Signaling Receptor Binding Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Neurotransmitter Binding Protein-containing Complex Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Angiogenesis Urogenital System Development Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Or Memory Learning Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Inactivation Of MAPKK Activity Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Projection Retraction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of NMDA Glutamate Receptor Activity	MAPK Cascade Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Chemical Synaptic Transmission Brain Development Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Sensory Perception Of Pain Calcium-mediated Signaling Pons Maturation Cerebral Cortex Development Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Heterotetramerization Regulation Of Synapse Assembly Calcium Ion Homeostasis Excitatory Postsynaptic Potential Prepulse Inhibition Male Mating Behavior Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Localization To Postsynaptic Membrane Cellular Response To Amyloid-beta Response To Glycine Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester	Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Memantine Orphenadrine Phenobarbital Prasterone Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		38 interacting genes: ABL1 ABL2 ACP1 AFDN AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERBB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1	54 interacting genes: ACTN2 AKAP9 APP CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		2048	2902
HPRD ID		02997	15926
Ensembl ID		ENSG00000133216	ENSG00000176884
Uniprot IDs		B4DSE0 P29323 Q4LE53 Q6NVW1	Q05586 Q59GW0 Q5VSF9
PDB IDs		1B4F 1F0M 2QBX 3ZFM	2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH
Enriched GO Terms of Interacting Partners?
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