GRIN1 and GRIN3A

Number of citations of the paper that reports this interaction (PubMedID 9620802)
122

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GRIN1	GRIN3A
Description		glutamate ionotropic receptor NMDA type subunit 1	glutamate ionotropic receptor NMDA type subunit 3A
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Membrane Integral Component Of Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Signaling Receptor Binding Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Neurotransmitter Binding Protein-containing Complex Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	NMDA Glutamate Receptor Activity Calcium Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity Glycine Binding Signaling Receptor Activity Identical Protein Binding Protein Phosphatase 2A Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	MAPK Cascade Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Chemical Synaptic Transmission Brain Development Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Sensory Perception Of Pain Calcium-mediated Signaling Pons Maturation Cerebral Cortex Development Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Heterotetramerization Regulation Of Synapse Assembly Calcium Ion Homeostasis Excitatory Postsynaptic Potential Prepulse Inhibition Male Mating Behavior Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Localization To Postsynaptic Membrane Cellular Response To Amyloid-beta Response To Glycine Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cysteine-type Endopeptidase Activity	Calcium Ion Transport Dendrite Development Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Prepulse Inhibition Calcium Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors
Drugs		Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Memantine Orphenadrine Phenobarbital Prasterone Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)	Glutamic Acid Tramadol Atomoxetine Pentobarbital Methadone Ethopropazine Secobarbital Dextromethorphan Acamprosate Procaine Ethanol Amantadine Felbamate Gabapentin Memantine Halothane Chloroprocaine Orphenadrine Phenobarbital Ketamine Tenocyclidine Rolicyclidine Prasterone Phencyclidine Milnacipran Neramexane Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Alzheimer disease and age of onset ( 26830138) Asthma ( 27611488) Coronary artery aneurysm in Kawasaki disease ( 26434682) Coronary artery calcification ( 23870195) Glucocorticoid-induced osteonecrosis ( 26265699) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Response to fenofibrate (triglyceride levels) ( 27002377) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		54 interacting genes: ACTN2 AKAP9 APP CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	6 interacting genes: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B PTPA
Entrez ID		2902	116443
HPRD ID		15926	09443
Ensembl ID		ENSG00000176884	ENSG00000198785
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	Q8TCU5
PDB IDs		2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH
Enriched GO Terms of Interacting Partners?
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