EEF2 and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 12171600)
34

Data Source:
HPRD (in vitro)

		EEF2	MAPKAPK3
Description		eukaryotic translation elongation factor 2	MAPK activated protein kinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Secretory Granule Lumen Polysomal Ribosome Membrane Raft Synapse Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	P53 Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding 5S RRNA Binding Protein Kinase Binding Ribosome Binding Cadherin Binding Actin Filament Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Response To Ischemia Skeletal Muscle Contraction Translational Elongation Aging Glial Cell Proliferation Response To Estradiol Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Response To Hydrogen Peroxide Neutrophil Degranulation Response To Ethanol Positive Regulation Of Translation Response To Folic Acid Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Cytoplasmic Translation	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation	p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs		Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE	2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS			Blood protein levels ( 28240269) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331)
Interacting Genes		18 interacting genes: CCT2 CDKN2A DISC1 EEF2K EP300 ESR1 HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B PTEN TP53 TRPM7 UCHL5	21 interacting genes: APP ATF1 BECN1 CHMP2A COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		1938	7867
HPRD ID		00561	03678
Ensembl ID		ENSG00000167658	ENSG00000114738
Uniprot IDs		A0A384N6H1 P13639	A0A024R2W7 Q16644
PDB IDs		4V6X 6D9J	3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?
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