EEF2 and PPP2R1B

Number of citations of the paper that reports this interaction (PubMedID 17540176)
91

Data Source:
HPRD (in vivo)

		EEF2	PPP2R1B
Description		eukaryotic translation elongation factor 2	protein phosphatase 2 scaffold subunit Abeta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Secretory Granule Lumen Polysomal Ribosome Membrane Raft Synapse Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Protein Phosphatase Type 2A Complex Cytoplasm Protein Serine/threonine Phosphatase Complex Membrane Raft Extracellular Exosome
	Molecular Function	P53 Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding 5S RRNA Binding Protein Kinase Binding Ribosome Binding Cadherin Binding Actin Filament Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Response To Ischemia Skeletal Muscle Contraction Translational Elongation Aging Glial Cell Proliferation Response To Estradiol Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Response To Hydrogen Peroxide Neutrophil Degranulation Response To Ethanol Positive Regulation Of Translation Response To Folic Acid Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Cytoplasmic Translation	Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs		Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		18 interacting genes: CCT2 CDKN2A DISC1 EEF2K EP300 ESR1 HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B PTEN TP53 TRPM7 UCHL5	42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 HYOU1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 TIMM8B UNC5B
Entrez ID		1938	5519
HPRD ID		00561	04384
Ensembl ID		ENSG00000167658	ENSG00000137713
Uniprot IDs		A0A384N6H1 P13639	P30154
PDB IDs		4V6X 6D9J
Enriched GO Terms of Interacting Partners?
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