ABCA1 and DLG5

Number of citations of the paper that reports this interaction (PubMedID 16192281)
8

Data Source:
HPRD (in vitro)

		ABCA1	DLG5
Description		ATP binding cassette subfamily A member 1	discs large MAGUK scaffold protein 5
Image
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Cell Junction Ciliary Basal Body
	Molecular Function	Signaling Receptor Binding Lipid Transporter Activity Protein Binding ATP Binding High-density Lipoprotein Particle Binding Cholesterol Binding ATPase Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances ATPase Binding Phosphatidylcholine-translocating ATPase Activity Phosphatidylserine-translocating ATPase Activity Intermembrane Cholesterol Transfer Activity	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Protein Lipidation Lipid Transport Phagocytosis, Engulfment Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Interleukin-1 Beta Secretion Transmembrane Transport Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly	Epithelial To Mesenchymal Transition Signal Transduction Negative Regulation Of Cell Proliferation Maintenance Of Cell Polarity Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion
Pathways		PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		ATP Glyburide Probucol
Diseases		Tangier disease Hypoalphalipoproteinemia
GWAS		Advanced age-related macular degeneration ( 26691988) Allergic rhinitis ( 25085501) Aluminium levels ( 26025379) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Cardiometabolic and hematological traits ( 27668658) Cholesterol, total ( 24097068 25961943 20686565 26582766) Coronary artery disease ( 29212778) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 25173107) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105 29452408) Gout ( 22179738) HDL cholesterol ( 24097068 21909109 28270201 18193043 18193044 20864672 26160806 19060906 23505323 19060911 30275531 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 31694877 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 30718733 29403010 29615537) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 28073927 30591961 29235454) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 30275531) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219) Low high density lipoprotein cholesterol levels ( 26879886) Lung cancer in ever smokers ( 28604730) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolite levels ( 31628463 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Myopia (pathological) ( 23049088) Pelvic organ prolapse ( 26545240) Periodontitis (Mean PAL) ( 24024966) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (total cholesterol levels) ( 27002377) Total cholesterol levels ( 28334899 29403010 30275531) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Alanine transaminase levels ( 29403010) Gamma glutamyl transferase levels ( 29403010) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macular thickness ( 30535121) Obesity-related traits ( 23251661)
Interacting Genes		42 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN ERP44 FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2	8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		19	9231
HPRD ID		02501	04972
Ensembl ID		ENSG00000165029	ENSG00000151208
Uniprot IDs		B2RUU2 B7XCW9 O95477	Q8TDM6
PDB IDs		5XJY	1UIT
Enriched GO Terms of Interacting Partners?
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