DVL1 and VANGL2

Number of citations of the paper that reports this interaction (PubMedID 12490194)
100

Data Source:
HPRD (in vitro)

		DVL1	VANGL2
Description		dishevelled segment polarity protein 1	VANGL planar cell polarity protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Postsynaptic Density Lateral Plasma Membrane Clathrin-coated Vesicle Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Wnt Signalosome	Stress Fiber Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole
	Molecular Function	Molecular_function Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Rac GTPase Binding	Protein Binding
	Biological Process	Regulation Of Neurotransmitter Levels Positive Regulation Of Protein Phosphorylation Transcription By RNA Polymerase II Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Presynapse Assembly Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Axis Elongation Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Positive Regulation Of JUN Kinase Activity Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Planar Cell Polarity Pathway Involved In Heart Morphogenesis Cochlea Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Axon Guidance Non-motile Cilium Assembly
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	PCP/CE pathway Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Cognitive performance ( 19734545) Multiple sclerosis ( 31604244 24076602) Systemic lupus erythematosus ( 28714469)
Interacting Genes		35 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BRD7 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FRAT1 HDHD2 HECW1 LRRK2 NCK2 NEDD4 PPM1A PSMA3 RAC1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 TRIM69 USP13 VANGL1 VANGL2	5 interacting genes: AP1M1 ARFRP1 DVL1 MAGI3 SQSTM1
Entrez ID		1855	57216
HPRD ID		03220	02758
Ensembl ID		ENSG00000107404	ENSG00000162738
Uniprot IDs		O14640	A8K4L6 Q9ULK5
PDB IDs
Enriched GO Terms of Interacting Partners?
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