VANGL2 and SQSTM1

Number of citations of the paper that reports this interaction (PubMedID 26754771)
27

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		VANGL2	SQSTM1
Description		VANGL planar cell polarity protein 2	sequestosome 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole	Phagophore Assembly Site P-body Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Intracellular Membrane-bounded Organelle Amphisome Autolysosome Extracellular Exosome Sperm Midpiece Lewy Body
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Axis Elongation Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Positive Regulation Of JUN Kinase Activity Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Planar Cell Polarity Pathway Involved In Heart Morphogenesis Cochlea Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Axon Guidance Non-motile Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Positive Regulation Of Protein Phosphorylation Immune System Process Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Apoptotic Process Mitochondrion Organization Endosome Organization Protein Localization Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Selective Autophagy Interleukin-1-mediated Signaling Pathway Response To Mitochondrial Depolarisation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		PCP/CE pathway Asymmetric localization of PCP proteins	NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Pink/Parkin Mediated Mitophagy Interleukin-1 signaling Pexophagy
Drugs
Diseases			Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Cognitive performance ( 19734545) Multiple sclerosis ( 31604244 24076602) Systemic lupus erythematosus ( 28714469)	Alzheimer's disease (late onset) ( 24162737)
Interacting Genes		5 interacting genes: AP1M1 ARFRP1 DVL1 MAGI3 SQSTM1	98 interacting genes: ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CAMK2A CCNB1 CDC6 CDK1 CRBN CRYAB CSNK1A1 CSNK2A1 DAZAP2 DNAI1 DNAI2 DNAJC10 EEF1D FKBP4 GABARAP GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPB1 IRAK1 ISG15 KCNAB2 LCK LRRK2 MALT1 MAP1LC3B MAP1LC3C MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MTDH NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PADI1 PAWR PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TBK1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIB3 TRIM21 TRIM55 TRIM63 TTN UBA52 UBB UBC UBE2D2 UBE2D3 ULK2 VANGL2 WDR81 XIAP YWHAZ
Entrez ID		57216	8878
HPRD ID		02758	03319
Ensembl ID		ENSG00000162738	ENSG00000161011
Uniprot IDs		A8K4L6 Q9ULK5	Q13501
PDB IDs			1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6MJ7
Enriched GO Terms of Interacting Partners?
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