DRD5 and GABRG2

Number of citations of the paper that reports this interaction (PubMedID 10659839)
90

Data Source:
HPRD (in vitro, in vivo)

		DRD5	GABRG2
Description		dopamine receptor D5	gamma-aminobutyric acid type A receptor subunit gamma2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cilium Brush Border Membrane Synapse Ciliary Membrane Non-motile Cilium	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Cytoplasmic Vesicle Membrane Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity Dopamine Binding	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Behavior Associative Learning Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Reactive Oxygen Species Metabolic Process	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Ziprasidone Cabergoline Cabergoline Ropinirole Olanzapine Olanzapine Mirtazapine Loxapine Loxapine Pramipexole Imipramine Chlorpromazine Chlorpromazine Cinnarizine Lisuride Ergotamine Apomorphine Trimipramine Fenoldopam Dopamine Dopamine Carphenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine Mianserin Quinagolide	Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Zolpidem Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Adipiplon Stiripentol Etizolam Thiocolchicoside Muscimol Lormetazepam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Impulsivity (motor) ( 30718321) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolite levels ( 23823483)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		5 interacting genes: GABRG2 GNA12 GNA13 GNAZ NCS1	8 interacting genes: DRD5 GABARAP GABRA2 LARP7 PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		1816	2566
HPRD ID		00542	00663
Ensembl ID		ENSG00000169676	ENSG00000113327
Uniprot IDs		P21918	P18507
PDB IDs			6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53
Enriched GO Terms of Interacting Partners?
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