DPYSL2 and NUMB

Number of citations of the paper that reports this interaction (PubMedID 11121447)
113

Data Source:
HPRD (in vitro, in vivo)

		DPYSL2	NUMB
Description		dihydropyrimidinase like 2	NUMB endocytic adaptor protein
Image
GO Annotations	Cellular Component	Cytosol Microtubule Plasma Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Early Endosome Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Microtubule Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Identical Protein Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Axon Guidance Brain Development Regulation Of Axon Extension	Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		CRMPs in Sema3A signaling Recycling pathway of L1	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state
Drugs		Artenimol
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Macular thickness ( 30535121) Multisite chronic pain ( 31194737)
Interacting Genes		14 interacting genes: AP2A1 CRMP1 DISC1 DPYSL4 DPYSL5 GORASP2 GSK3B LEF1 NUMB PLD2 ROCK1 TNIK TUBB UBE2I	33 interacting genes: AP2A1 AP2A2 APP DNAJC5 DPYSL2 EGFR EPS15 FBXO7 FRS3 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 OLIG1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 TERF2
Entrez ID		1808	8650
HPRD ID		03914	04767
Ensembl ID		ENSG00000092964	ENSG00000133961
Uniprot IDs		A0A1C7CYX9 Q16555 Q59GB4	A0A024R681 A0A024R684 A0A024R6C4 A0A024R6F4 P49757
PDB IDs		2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB	5NJJ 5NJK
Enriched GO Terms of Interacting Partners?
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