DPYSL2 and PLD2

Number of citations of the paper that reports this interaction (PubMedID 11741937)
10

Data Source:
HPRD (in vitro, in vivo)

		DPYSL2	PLD2
Description		dihydropyrimidinase like 2	phospholipase D2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Plasma Membrane Membrane Extracellular Exosome	Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Presynapse
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Microtubule Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Identical Protein Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Axon Guidance Brain Development Regulation Of Axon Extension	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility
Pathways		CRMPs in Sema3A signaling Recycling pathway of L1	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis
Drugs		Artenimol	Choline
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)
Interacting Genes		14 interacting genes: AP2A1 CRMP1 DISC1 DPYSL4 DPYSL5 GORASP2 GSK3B LEF1 NUMB PLD2 ROCK1 TNIK TUBB UBE2I	30 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 TIMM10B VHL
Entrez ID		1808	5338
HPRD ID		03914	03857
Ensembl ID		ENSG00000092964	ENSG00000129219
Uniprot IDs		A0A1C7CYX9 Q16555 Q59GB4	O14939
PDB IDs		2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB
Enriched GO Terms of Interacting Partners?
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