AFP and PHB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		AFP	PHB2
Description		alpha fetoprotein	prohibitin 2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Fatty Acid Binding Protein Binding Zinc Ion Binding	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Sphingolipid Binding Protein N-terminus Binding
	Biological Process	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process SMAD Protein Signal Transduction	Protein Import Into Nucleus Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Sister Chromatid Cohesion Response To Wounding Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Processing of SMDT1
Drugs			Capsaicin
Diseases
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)	Glycated hemoglobin levels ( 28898252) Red blood cell fatty acid levels ( 25500335)
Interacting Genes		10 interacting genes: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP	19 interacting genes: AFP AKT1 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PRKCA PTMA RNF2 TEAD3 UPF2
Entrez ID		174	11331
HPRD ID		00074	17843
Ensembl ID		ENSG00000081051	ENSG00000215021
Uniprot IDs		P02771	Q99623
PDB IDs		3MRK	6IQE
Enriched GO Terms of Interacting Partners?
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