DHPS and UPF1

		DHPS	UPF1
Description		deoxyhypusine synthase	UPF1 RNA helicase and ATPase
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nuclear Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	Protein Binding Deoxyhypusine Synthase Activity Identical Protein Binding	Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Telomeric DNA Binding
	Biological Process	Translation Spermidine Metabolic Process Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1
Pathways		Hypusine synthesis from eIF5A-lysine	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		1-Guanidinium-7-Aminoheptane
Diseases
GWAS
Interacting Genes		13 interacting genes: BRCA1 EIF5A EIF5A2 NIF3L1 NTAQ1 NUDT18 PTPRH RAB27B REL RPL9 UPF1 VASH1 ZNF138	36 interacting genes: ABHD16A ACRV1 ACSS2 AP1G1 ATR CNN1 CSNK2B DCP1A DCP2 DHPS DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LDB1 LSM8 NADSYN1 NDRG1 NDUFB10 NOTCH3 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		1725	5976
HPRD ID		02969	03254
Ensembl ID		ENSG00000095059	ENSG00000005007
Uniprot IDs		A0A024R7D0 A0A024R7E9 P49366	A0A024R7L5 A0A024R7L8 B3KY55 Q92900
PDB IDs		1DHS 1RLZ 1ROZ 1RQD	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5
Enriched GO Terms of Interacting Partners?
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