DCTN1 and KIAA0408

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		DCTN1	KIAA0408
Description		dynactin subunit 1	KIAA0408
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Cell Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage
	Molecular Function	Motor Activity Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle ER To Golgi Vesicle-mediated Transport Nervous System Development Neuromuscular Junction Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Microtubule Anchoring At Centrosome IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Envelope Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Perry syndrome Distal hereditary motor neuropathies (dHMN)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)	Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 HSPB2 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TMED5 VIM ZNF512B	26 interacting genes: ABI3 AP2B1 BEGAIN CARD9 CCDC85B CEP72 DCTN1 DTNBP1 GFAP HOOK2 KDM1A KRT15 MAGEA11 MDFI PFDN1 PRMT6 SFN SORBS3 TEX11 TLE1 TRAF2 TRIM37 VIM XRCC6 YWHAG ZDHHC17
Entrez ID		1639	9729
HPRD ID		07206	17187
Ensembl ID		ENSG00000204843	ENSG00000189367
Uniprot IDs		Q14203 Q6MZZ3	Q6ZU52
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?
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