DCTN1 and BBS1

Number of citations of the paper that reports this interaction (PubMedID 18000879)
7

Data Source:
BioGRID (two hybrid)

		DCTN1	BBS1
Description		dynactin subunit 1	Bardet-Biedl syndrome 1
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Cell Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Motor Activity Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle ER To Golgi Vesicle-mediated Transport Nervous System Development Neuromuscular Junction Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Microtubule Anchoring At Centrosome IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Envelope Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance	Visual Perception Sensory Perception Of Smell Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Cilium Assembly Protein Localization To Cilium Non-motile Cilium Assembly
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Perry syndrome Distal hereditary motor neuropathies (dHMN)	Bardet-Biedl syndrome (BBS)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)	Bipolar disorder ( 21926972) Height ( 28552196)
Interacting Genes		45 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 HSPB2 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TMED5 VIM ZNF512B	13 interacting genes: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7
Entrez ID		1639	582
HPRD ID		07206	01950
Ensembl ID		ENSG00000204843	ENSG00000174483
Uniprot IDs		Q14203 Q6MZZ3	Q8NFJ9
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?
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