CD55 and CD14

Number of citations of the paper that reports this interaction (PubMedID 11745332)
62

Data Source:
HPRD (in vitro)

		CD55	CD14
Description		CD55 molecule (Cromer blood group)	CD14 molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cell Plasma Membrane Cell Surface Transport Vesicle Secretory Granule Membrane Anchored Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Lipid Binding	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Cytokine Production Neutrophil Degranulation Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Viral Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Neutrophil Degranulation Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Necroptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-8 Secretion
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		Chloramphenicol
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	Asthma
GWAS		Blood protein levels ( 30072576 29875488 28240269) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Blood protein levels ( 30072576) Schizophrenia ( 29483656)
Interacting Genes		6 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK	15 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 REEP5 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		1604	929
HPRD ID		00500	01151
Ensembl ID		ENSG00000196352	ENSG00000170458
Uniprot IDs		B1AP13 P08174	P08571
PDB IDs		1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK	4GLP
Enriched GO Terms of Interacting Partners?
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