RHOXF1 and NPAS2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		RHOXF1	NPAS2
Description		Rhox homeobox family member 1	neuronal PAS domain protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Gamete Generation Positive Regulation Of Gene Expression Sexual Reproduction Intracellular Steroid Hormone Receptor Signaling Pathway	Cellular Response To DNA Damage Stimulus Central Nervous System Development Circadian Rhythm Regulation Of Lipid Metabolic Process Circadian Regulation Of Gene Expression Response To Drug Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Redox State Negative Regulation Of Cell Death Positive Regulation Of Behavioral Fear Response Regulation Of Response To DNA Damage Stimulus
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Circadian Clock Circadian Clock
Drugs
Diseases
GWAS			Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Intraocular pressure ( 31798171 31959993 30054594) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Pulse pressure ( 27841878)
Interacting Genes		2 interacting genes: NPAS2 VTN	24 interacting genes: ARNT2 ARNTL CLOCK CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 KAT2B NCOA3 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 ZSCAN1
Entrez ID		158800	4862
HPRD ID		15954	09137
Ensembl ID		ENSG00000101883	ENSG00000170485
Uniprot IDs		Q8NHV9	A2I2P5 Q99743
PDB IDs
Enriched GO Terms of Interacting Partners?
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