NPAS2 and CRX

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		NPAS2	CRX
Description		neuronal PAS domain protein 2	cone-rod homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Central Nervous System Development Circadian Rhythm Regulation Of Lipid Metabolic Process Circadian Regulation Of Gene Expression Response To Drug Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Redox State Negative Regulation Of Cell Death Positive Regulation Of Behavioral Fear Response Regulation Of Response To DNA Damage Stimulus	Regulation Of Transcription, DNA-templated Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Stimulus
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Circadian Clock Circadian Clock
Drugs
Diseases			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Intraocular pressure ( 31798171 31959993 30054594) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Pulse pressure ( 27841878)
Interacting Genes		24 interacting genes: ARNT2 ARNTL CLOCK CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 KAT2B NCOA3 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 ZSCAN1	54 interacting genes: ABI2 ACBD4 ATG12 ATM ATXN7 BANF1 BANP C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 DELE1 EIF5A EP300 GCM2 GUCD1 HGS IPO13 KAT2A KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PDC PICALM PID1 PPP1R16B PRKAB2 PRKN PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS ROR2 SFI1 SMAD3 SMUG1 SOX5 STK16 SZT2 TLE5 UBXN2B ZNF688
Entrez ID		4862	1406
HPRD ID		09137	03748
Ensembl ID		ENSG00000170485	ENSG00000105392
Uniprot IDs		A2I2P5 Q99743	O43186
PDB IDs
Enriched GO Terms of Interacting Partners?
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