CTSZ and KRTAP5-9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CTSZ	KRTAP5-9
Description		cathepsin Z	keratin associated protein 5-9
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Growth Cone Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Cell Cortex Region Ficolin-1-rich Granule Lumen	Cytosol Keratin Filament
	Molecular Function	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding
	Biological Process	Angiotensin Maturation Proteolysis ER To Golgi Vesicle-mediated Transport Negative Regulation Of Plasminogen Activation Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Binding Neutrophil Degranulation Positive Regulation Of Neuron Apoptotic Process COPII Vesicle Coating Proteolysis Involved In Cellular Protein Catabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Neural Precursor Cell Proliferation	Epidermis Development Keratinization
Pathways		Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation	Keratinization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 24026423 27863252) Platelet distribution width ( 27863252)
Interacting Genes		6 interacting genes: KRT40 KRTAP5-9 MID2 MTUS2 NOTCH2NLA PLSCR1	107 interacting genes: ABHD17A ADAMTSL4 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CKS1B CNNM3 COMT CRCT1 CREB5 CTSZ CXCL16 DHRS1 DMRT3 DOCK2 FAH FAM124B FAM161A FAM74A4 FAM76B GLRX3 GNE HOXA1 HOXB9 HPCAL1 HSPD1 JOSD1 KLHL38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE3C LCE3E LCE4A LY6H MAPKBP1 MEOX2 NAXD NCLN NECTIN2 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 PCSK5 PFKL PGLS POM121L8P PRKAB2 PSMA1 PTPMT1 RAMP3 RGS20 RNF111 SCARB1 SDC3 SDCBP SHFL SLC22A23 SLC25A10 SMCP SPATC1L SPG7 SPINK2 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TOMM22 TYRO3 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF417 ZNF439 ZNF581 ZNF587
Entrez ID		1522	3846
HPRD ID		04410	01008
Ensembl ID		ENSG00000101160	ENSG00000254997
Uniprot IDs		Q9UBR2	P26371
PDB IDs		1DEU 1EF7
Enriched GO Terms of Interacting Partners?
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