KRTAP5-9 and DOCK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	DOCK2
Description		keratin associated protein 5-9	dedicator of cytokinesis 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding
	Biological Process	Epidermis Development Keratinization	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Neutrophil Degranulation Positive Regulation Of GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis
Pathways		Keratinization	Nef and signal transduction Neutrophil degranulation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		107 interacting genes: ABHD17A ADAMTSL4 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CKS1B CNNM3 COMT CRCT1 CREB5 CTSZ CXCL16 DHRS1 DMRT3 DOCK2 FAH FAM124B FAM161A FAM74A4 FAM76B GLRX3 GNE HOXA1 HOXB9 HPCAL1 HSPD1 JOSD1 KLHL38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE3C LCE3E LCE4A LY6H MAPKBP1 MEOX2 NAXD NCLN NECTIN2 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 PCSK5 PFKL PGLS POM121L8P PRKAB2 PSMA1 PTPMT1 RAMP3 RGS20 RNF111 SCARB1 SDC3 SDCBP SHFL SLC22A23 SLC25A10 SMCP SPATC1L SPG7 SPINK2 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TOMM22 TYRO3 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF417 ZNF439 ZNF581 ZNF587	27 interacting genes: CALCOCO2 CCNDBP1 CD247 CRKL ELMO1 HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTDH MTUS2 NOTCH2NLA PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1
Entrez ID		3846	1794
HPRD ID		01008	09121
Ensembl ID		ENSG00000254997	ENSG00000134516
Uniprot IDs		P26371	Q5XG91 Q92608
PDB IDs			2RQR 2YIN 3A98 3B13
Enriched GO Terms of Interacting Partners?
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