SGO1 and PPP2R5A

Number of citations of the paper that reports this interaction (PubMedID 16541025)
217

Data Source:
HPRD (in vivo)

		SGO1	PPP2R5A
Description		shugoshin 1	protein phosphatase 2 regulatory subunit B'alpha
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleoplasm Centrosome Cytosol Nuclear Body	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Centrosome Cytosol Membrane Z Disc M Band
	Molecular Function	Protein Binding Kinase Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Nickel levels ( 26025379)
Interacting Genes		20 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6	18 interacting genes: APC BCL2 BEST1 CHEK2 CSNK1A1 CTLA4 DAPK1 EIF2AK2 GNL3 JAK2 MAPT NEK1 NOS3 PPP2R1A PTTG1 SGO1 SHC1 TP63
Entrez ID		151648	5525
HPRD ID		12377	03384
Ensembl ID		ENSG00000129810	ENSG00000066027
Uniprot IDs		A0A024R2J4 B5BUA4 Q5FBB7	Q15172
PDB IDs		3FGA 3Q6S 4A0I
Enriched GO Terms of Interacting Partners?
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