PPP2R5A and CTLA4

Number of citations of the paper that reports this interaction (PubMedID 11994459)
26

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vivo)

		PPP2R5A	CTLA4
Description		protein phosphatase 2 regulatory subunit B'alpha	cytotoxic T-lymphocyte associated protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Centrosome Cytosol Membrane Z Disc M Band	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity	Protein Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Protein Localization To Plasma Membrane	Adaptive Immune Response Immune System Process Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs			Ipilimumab
Diseases			Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis
GWAS		Nickel levels ( 26025379)	Alopecia areata ( 20596022 25608926) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Type 1 diabetes ( 21829393 25751624 19430480 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		18 interacting genes: APC BCL2 BEST1 CHEK2 CSNK1A1 CTLA4 DAPK1 EIF2AK2 GNL3 JAK2 MAPT NEK1 NOS3 PPP2R1A PTTG1 SGO1 SHC1 TP63	15 interacting genes: AP1M1 AP2M1 BCS1L CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK
Entrez ID		5525	1493
HPRD ID		03384	00474
Ensembl ID		ENSG00000066027	ENSG00000163599
Uniprot IDs		Q15172	P16410
PDB IDs			1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3
Enriched GO Terms of Interacting Partners?
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