CTSD and IGF2R

Number of citations of the paper that reports this interaction (PubMedID 15258139)
29

Data Source:
HPRD (in vivo)

		CTSD	IGF2R
Description		cathepsin D	insulin like growth factor 2 receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nuclear Envelope Lumen Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Vesicle Membrane Secretory Granule Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor-activated Receptor Activity Protein Binding Insulin-like Growth Factor Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein Catabolic Process Collagen Catabolic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Regulation Of Establishment Of Protein Localization	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation By Host Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression	Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Insulin Human Insulin Pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	Hepatocellular carcinoma
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) Lipoprotein (a) levels ( 26377243) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		23 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NLGN3 PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3
Entrez ID		1509	3482
HPRD ID		00291	00928
Ensembl ID		ENSG00000117984	ENSG00000197081
Uniprot IDs		P07339 V9HWI3	P11717
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y
Enriched GO Terms of Interacting Partners?
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