CTSD and SPRED2

Number of citations of the paper that reports this interaction (PubMedID 30771306)
2

Data Source:
BioGRID (pull down)

		CTSD	SPRED2
Description		cathepsin D	sprouty related EVH1 domain containing 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytosol Plasma Membrane Transport Vesicle Membrane
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein Catabolic Process Collagen Catabolic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Regulation Of Establishment Of Protein Localization	Inactivation Of MAPK Activity Multicellular Organism Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression	Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs		Insulin Human Insulin Pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Gamma glutamyl transferase levels ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 27863252)
Interacting Genes		23 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NLGN3 PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	7 interacting genes: CTSD KIT MTDH RHOA SPG21 TOP3B ZDHHC17
Entrez ID		1509	200734
HPRD ID		00291	18100
Ensembl ID		ENSG00000117984	ENSG00000198369
Uniprot IDs		P07339 V9HWI3	B3KPL5 Q7Z698
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	2JP2
Enriched GO Terms of Interacting Partners?
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