CTNNB1 and STUB1

Number of citations of the paper that reports this interaction (PubMedID 29326975)
4

Data Source:
BioGRID (enzymatic study)

		CTNNB1	STUB1
Description		catenin beta 1	STIP1 homology and U-box containing protein 1
Image
GO Annotations	Cellular Component	Spindle Pole Cell Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Bicellular Tight Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Microvillus Membrane Protein-containing Complex Protein-DNA Complex Scrib-APC-beta-catenin Complex Presynaptic Membrane Apical Part Of Cell Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery Schaffer Collateral - CA1 Synapse Presynaptic Active Zone Cytoplasmic Component Postsynaptic Density, Intracellular Component Beta-catenin-TCF Complex Wnt Signalosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Chaperone Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding Androgen Receptor Binding I-SMAD Binding Repressing Transcription Factor Binding Disordered Domain Specific Binding	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Embryonic Axis Specification Cell Morphogenesis Involved In Differentiation Branching Involved In Blood Vessel Morphogenesis Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Epithelial To Mesenchymal Transition Neural Plate Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Morphogenesis In Camera-type Eye Regulation Of Secondary Heart Field Cardioblast Proliferation Metanephros Morphogenesis Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Adhesion Cell-matrix Adhesion Wnt Signaling Pathway, Calcium Modulating Pathway Chemical Synaptic Transmission Ectoderm Development Glial Cell Fate Determination Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Proximal/distal Pattern Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Viral Process Wnt Signaling Pathway Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Layer Formation In Cerebral Cortex Central Nervous System Vasculogenesis Osteoclast Differentiation Androgen Receptor Signaling Pathway Male Genitalia Development Hindbrain Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Myelination Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Type I Interferon Production T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Entry Of Bacterium Into Host Cell Embryonic Skeletal Limb Joint Morphogenesis Astrocyte-dopaminergic Neuron Signaling Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Response To Drug Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Mitotic Cell Cycle, Embryonic Chromatin-mediated Maintenance Of Transcription Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Thymus Development Oocyte Development Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Neurogenesis Synapse Organization Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Timing Of Anagen Positive Regulation Of Telomerase Activity Oviduct Development Canonical Wnt Signaling Pathway Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Tube Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Cranial Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Calcium Ion Import Synaptic Vesicle Clustering Cell-cell Adhesion Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Chromatin-mediated Maintenance Of Transcription Regulation Of Euchromatin Binding Positive Regulation Of Core Promoter Binding Beta-catenin-TCF Complex Assembly Beta-catenin Destruction Complex Disassembly Cranial Skeletal System Development Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Neuron Projection Extension Embryonic Brain Development Dorsal Root Ganglion Development Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Apoptotic Signaling Pathway	Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling	Downregulation of TGF-beta receptor signaling Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Urea
Diseases		Gastric cancer Colorectal cancer Endometrial Cancer Pilomatricoma; Epithelioma calcificans of Malherbe Thyroid cancer Hepatocellular carcinoma
GWAS		Bone mineral density (hip) ( 27311723 19801982) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414) Systolic blood pressure ( 30224653)
Interacting Genes		187 interacting genes: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARFGEF1 ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL6 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC34 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBIN ESR1 EZR FBXW2 FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B H1-2 HIF1A HNF1A HUWE1 IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAP3K2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKM PKP2 PLK1 PPM1A PRKCG PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RET RUVBL1 RUVBL2 RXRA SALL1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SMURF1 SOX1 SOX17 SP1 SPN SRC STUB1 TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIM33 TRIP10 TRRAP UBE2B UBE2D1 UBE2R2 UBE2S UBE3A UHRF2 USP2 USP7 USP9X ZFYVE9 ZIC3	123 interacting genes: ABL1 ACD AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BCR BMPR1B CCL28 CDK4 CDKN1A CFTR CIP2A CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A1 GUCY1A2 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 INSR JOSD1 JOSD2 KHDRBS1 LRRK1 LRRK2 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 PA2G4 PFN1 PLK1 POLB POT1 POU5F1 PPARG PPP3CA PRKACA PRKCZ PRKN PRMT1 PRMT5 PSMA3 PSMD4 PTEN RAF1 RHBDF2 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TPD52 TRAF6 TXN2 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W VCP XIAP
Entrez ID		1499	10273
HPRD ID		00286	06232
Ensembl ID		ENSG00000168036	ENSG00000103266
Uniprot IDs		A0A024R2Q3 B4DGU4 P35222	Q9UNE7
PDB IDs		1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS 6M90 6M91 6M92 6M93 6M94 6O9B 6O9C	4KBQ 6EFK 6NSV
Enriched GO Terms of Interacting Partners?
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