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STUB1 and MAP3K21
Number of citations of the paper that reports this interaction (PubMedID
28757353
)
1
Data Source:
BioGRID
(pull down, enzymatic study)
STUB1
MAP3K21
Description
STIP1 homology and U-box containing protein 1
mitogen-activated protein kinase kinase kinase 21
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Chaperone Complex
Cellular_component
Molecular Function
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein Binding, Bridging
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Biological Process
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Heat
ERBB2 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Protein Maturation
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Activation Of MAPKK Activity
Protein Phosphorylation
Activation Of JUN Kinase Activity
Protein Autophosphorylation
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes
123 interacting genes:
ABL1
ACD
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BCR
BMPR1B
CCL28
CDK4
CDKN1A
CFTR
CIP2A
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FOXP3
GHR
GPR37
GUCY1A1
GUCY1A2
HIF1A
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
INSR
JOSD1
JOSD2
KHDRBS1
LRRK1
LRRK2
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
PA2G4
PFN1
PLK1
POLB
POT1
POU5F1
PPARG
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PRMT5
PSMA3
PSMD4
PTEN
RAF1
RHBDF2
RUNX2
RUSC1
S100A2
S100P
SIRT6
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TPD52
TRAF6
TXN2
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
VCP
XIAP
4 interacting genes:
CLK1
MAP3K10
MAP3K11
STUB1
Entrez ID
10273
84451
HPRD ID
06232
10087
Ensembl ID
ENSG00000103266
ENSG00000143674
Uniprot IDs
Q9UNE7
Q5TCX8
PDB IDs
4KBQ
6EFK
6NSV
4UYA
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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