IL23R and C1D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		IL23R	C1D
Description		interleukin 23 receptor	C1D nuclear receptor corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Receptor Complex Interleukin-23 Receptor Complex	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Transcriptional Repressor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Maturation Of 5.8S RRNA RRNA Processing Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Crohn's disease
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187 21743469 20062062) Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 28067908 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 23850713 17804789) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 18758464 28067908 23128233) Inflammatory skin disease ( 25574825) Leprosy ( 25642632 22019778) Pediatric autoimmune diseases ( 26301688) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Psoriasis ( 25903422 20953190 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Sarcoidosis ( 26051272) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 19915572 28067908 26398853 20228799 21297633 19122664) Vogt-Koyanagi-Harada syndrome ( 25108386)	Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) Restless legs syndrome ( 29029846) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		5 interacting genes: C1D IL12RB1 IL23A JAK2 STAT3	12 interacting genes: APP IL23R MOGS NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 THRA THRB TSNAX
Entrez ID		149233	10438
HPRD ID		16249	07382
Ensembl ID		ENSG00000162594	ENSG00000197223
Uniprot IDs		Q5VWK5	Q13901
PDB IDs		5MZV
Enriched GO Terms of Interacting Partners?
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