C1D and MOGS

		C1D	MOGS
Description		C1D nuclear receptor corepressor	mannosyl-oligosaccharide glucosidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Transcriptional Repressor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding	Mannosyl-oligosaccharide Glucosidase Activity Glucosidase Activity
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Defective MOGS causes MOGS-CDG (CDG-2b) N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) Restless legs syndrome ( 29029846) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		12 interacting genes: APP IL23R MOGS NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 THRA THRB TSNAX	9 interacting genes: C1D CHGB ETAA1 EXOC6B MXD1 PCBP1 RAB11FIP5 REL VPS54
Entrez ID		10438	7841
HPRD ID		07382	03214
Ensembl ID		ENSG00000197223	ENSG00000115275
Uniprot IDs		Q13901	A0A384MDR6 Q13724 Q58F09
PDB IDs
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