PARP1 and E2F1

Number of citations of the paper that reports this interaction (PubMedID 14627987)
46

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		PARP1	E2F1
Description		poly(ADP-ribose) polymerase 1	E2F transcription factor 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Nucleolus Mitochondrion Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Site Of DNA Damage	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Centrosome Protein-containing Complex Rb-E2F Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Estrogen Receptor Binding Identical Protein Binding Histone Deacetylase Binding Protein N-terminus Binding NAD Binding R-SMAD Binding Protein ADP-ribosylase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Transcription By RNA Polymerase II Protein ADP-ribosylation Apoptotic Process Cellular Response To DNA Damage Stimulus Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of SMAD Protein Complex Assembly Protein Autoprocessing Peptidyl-serine ADP-ribosylation Peptidyl-glutamic Acid Poly-ADP-ribosylation Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleotide-excision Repair, DNA Incision Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process DNA Damage Response, Detection Of DNA Damage Mitochondrial DNA Repair Regulation Of DNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Global Genome Nucleotide-excision Repair Cellular Response To Zinc Ion Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Neuron Death Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Single Strand Break Repair Regulation Of Cellular Protein Localization Response To Aldosterone Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Generation From Poly-ADP-D-ribose Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of ATP Biosynthetic Process	DNA Damage Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Viral Process Forebrain Development Positive Regulation Of Apoptotic Process Anoikis Negative Regulation Of DNA Binding Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Regulation Of Cell Cycle Positive Regulation Of Glial Cell Proliferation Negative Regulation Of G0 To G1 Transition Negative Regulation Of Fat Cell Proliferation Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDC6 association with the ORC:origin complex G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs		Theophylline Zinc Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Niraparib Rucaparib
Diseases
GWAS		Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 29403010) Telomere length ( 29151059)	Heel bone mineral density ( 30598549) Height ( 31562340)
Interacting Genes		99 interacting genes: APTX ATM BCL2 BLID BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTCF CTSB CTSG E2F1 ERCC6 ERG ETS1 FOXO1 GTF2F1 GZMB GZMM H1-0 H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-3A H3-4 H4C3 HDAC1 HDAC3 HIPK2 HMGA1 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LZTR1 MACROH2A1 MED14 MED6 MTA3 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF144A RNF168 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	83 interacting genes: ARID3A ATAD2 ATM ATR BIN1 BIRC2 BRCA1 BRD2 BRMS1 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 CUL2 DDB2 DIABLO E2F6 EP300 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MPHOSPH10 MTA1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NFKB1 NPDC1 NRIP1 NSMCE3 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RBL1 RNF126 RNF144A SERTAD2 SETD7 SIRT1 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP UBE3A UCHL5 VHL YWHAQ
Entrez ID		142	1869
HPRD ID		01435	01806
Ensembl ID		ENSG00000143799	ENSG00000101412
Uniprot IDs		A0A024R3T8 P09874	Q01094 Q9BSD8
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6NRF 6NRG 6NRH 6NRI 6NRJ	1H24 1O9K 2AZE 5M9N 5M9O 6G0P
Enriched GO Terms of Interacting Partners?
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