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E2F1 and BIRC2
Number of citations of the paper that reports this interaction (PubMedID
28542143
)
5
Data Source:
BioGRID
(pull down, pull down)
E2F1
BIRC2
Description
E2F transcription factor 1
baculoviral IAP repeat containing 2
Image
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Factor Complex
XY Body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Proximal Promoter Sequence-specific DNA Binding
Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Ubiquitin Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
FBXO Family Protein Binding
Biological Process
DNA Damage Checkpoint
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Viral Process
Forebrain Development
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Regulation Of Cell Cycle
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Response To Hypoxia
Placenta Development
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Regulation Of RIG-I Signaling Pathway
Regulation Of Cell Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Response To Ethanol
Regulation Of Cell Differentiation
Regulation Of Inflammatory Response
Response To CAMP
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Necroptotic Process
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Protein K48-linked Ubiquitination
Positive Regulation Of Protein Monoubiquitination
Positive Regulation Of Nucleic Acid-templated Transcription
Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS
Heel bone mineral density (
30598549
)
Height (
31562340
)
Prostate cancer (
23535732
)
Interacting Genes
83 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MPHOSPH10
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
65 interacting genes:
ABHD17A
BIRC5
BOLA1
CASP3
CASP7
CASP9
CBLC
CD40
CDC42
CSE1L
DIABLO
DZIP3
E2F1
EAF2
EIF4E
EXOSC5
FBXO7
GAS1
GCC1
GFAP
GLMN
GSPT1
HSP90B1
HTRA2
IGF2BP1
IKBKE
IKBKG
JUP
LTBR
MAD1L1
MAGEA11
MAP3K2
MAP3K3
NMB
OTUB1
PACS2
PCSK9
PFN2
PPM1K
RAC1
RAF1
RHOA
RIPK2
RIPK3
RIPK4
RNF181
TRADD
TRAF1
TRAF2
TRIM34
TSG101
TSGA10
TUFT1
UBB
UBC
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2J1
UBE2N
UBE2Q2
UBE2S
UBE2V1
UBE2W
Entrez ID
1869
329
HPRD ID
01806
03419
Ensembl ID
ENSG00000101412
ENSG00000110330
Uniprot IDs
Q01094
Q9BSD8
Q13490
PDB IDs
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
1QBH
2L9M
3D9T
3D9U
3M1D
3MUP
3OZ1
3T6P
3UW4
4EB9
4HY4
4HY5
4KMN
4LGE
4LGU
4MTI
4MU7
5M6N
6EXW
6HPR
Enriched GO Terms of Interacting Partners
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