CRH and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 8243338)
65

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CRH	CRHR2
Description		corticotropin releasing hormone	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon Synapse	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Axon Terminus
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Negative Regulation Of Systemic Arterial Blood Pressure Glucocorticoid Biosynthetic Process Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Positive Regulation Of Cell Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Lung Development Adrenal Gland Development Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Locomotory Exploration Behavior Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Estrogen Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Response To Ether Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of NMDA Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events MECP2 regulates transcription of neuronal ligands ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production
Drugs		Corticotropin D-Phenylalanine Alpha-Aminoisobutyric Acid
Diseases
GWAS		Coronary heart disease event reduction (statin therapy interaction) ( 22666496)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		3 interacting genes: CRHR1 CRHR2 KRT31	6 interacting genes: APP CRH GCC1 UCN UCN2 UCN3
Entrez ID		1392	1395
HPRD ID		07172	03614
Ensembl ID		ENSG00000147571	ENSG00000106113
Uniprot IDs		A0A0S2Z478 P06850	A0A090N7T4 Q13324
PDB IDs		1GO9 1GOE 3EHT 3EHU	3N93 3N95 3N96
Enriched GO Terms of Interacting Partners?
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