CRHR2 and UCN

Number of citations of the paper that reports this interaction (PubMedID 11416224)
216

Data Source:
HPRD (in vivo, in vitro)

		CRHR2	UCN
Description		corticotropin releasing hormone receptor 2	urocortin
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Axon Terminus	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus
	Molecular Function	Protein Binding Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus	Startle Response Inflammatory Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Response To Auditory Stimulus Pancreatic Juice Secretion Positive Regulation Of Cell Growth Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways		G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production	Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Type 2 diabetes ( 24509480 30297969)	Crohn's disease ( 23128233)
Interacting Genes		6 interacting genes: APP CRH GCC1 UCN UCN2 UCN3	5 interacting genes: CRHBP CRHR1 CRHR2 LEP RAB18
Entrez ID		1395	7349
HPRD ID		03614	02970
Ensembl ID		ENSG00000106113	ENSG00000163794
Uniprot IDs		A0A090N7T4 Q13324	P55089
PDB IDs		3N93 3N95 3N96	2RMF 3N96
Enriched GO Terms of Interacting Partners?
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