NACC2 and MTA3

Number of citations of the paper that reports this interaction (PubMedID 22926524)
6

Data Source:
BioGRID (pull down)

		NACC2	MTA3
Description		NACC family member 2	metastasis associated 1 family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleolus Mitochondrion	Nucleus Nucleoplasm Cytoplasm NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding	RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Proliferation Histone Deacetylation Cellular Protein-containing Complex Localization Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Nucleic Acid-templated Transcription
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) SjÃ¶gren's syndrome ( 28076899) Ulcerative colitis ( 28067908)	Breastfeeding duration ( 25475840)
Interacting Genes		5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3	20 interacting genes: AKT1 ARNT ATM AURKA BAG4 BCAR3 BCL6 CDKN2C FGFR2 FGFR4 FOXK2 FZR1 GRB2 IGF1R KDM1A NACC2 NOTCH2 PARP1 TGFB1 TSG101
Entrez ID		138151	57504
HPRD ID		09831	12359
Ensembl ID		ENSG00000148411	ENSG00000057935
Uniprot IDs		A0A024R8I0 Q96BF6	F6RRE2 Q9BTC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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