COL10A1 and P4HB

Number of citations of the paper that reports this interaction (PubMedID 10436013)
62

Data Source:
HPRD (in vivo)

		COL10A1	P4HB
Description		collagen type X alpha 1 chain	prolyl 4-hydroxylase subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Peptide Disulfide Oxidoreductase Activity Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Skeletal System Development Extracellular Matrix Organization	Protein Folding Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Oxidation-reduction Process Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen chain trimerization	Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling
Drugs			Zinc Ribostamycin Copper
Diseases		Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Age-related macular degeneration ( 23455636 21665990) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Myopia ( 27182965) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: ANXA5 BANP P4HB UBQLN1	22 interacting genes: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1A ERO1B ESR1 FEZ1 HNRNPD ITGB3 LGALS9 LINC00839 P4HA2 P4HA3 PRNP PTN TG UBQLN1 VWF YWHAG
Entrez ID		1300	5034
HPRD ID		00357	07181
Ensembl ID		ENSG00000123500	ENSG00000185624
Uniprot IDs		Q03692	A0A024R8S5 P07237
PDB IDs		1GR3	1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S
Enriched GO Terms of Interacting Partners?
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