Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
P4HB and COL1A1
Number of citations of the paper that reports this interaction (PubMedID
1339453
)
20
Data Source:
HPRD
(in vitro)
P4HB
COL1A1
Description
prolyl 4-hydroxylase subunit beta
collagen type I alpha 1 chain
Image
GO Annotations
Cellular Component
Extracellular Region
Cell
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Cytoskeleton
Focal Adhesion
External Side Of Plasma Membrane
Procollagen-proline 4-dioxygenase Complex
Lamellipodium
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Extracellular Exosome
Extracellular Region
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Apparatus
Secretory Granule
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
RNA Binding
Protein Disulfide Isomerase Activity
Actin Binding
Procollagen-proline 4-dioxygenase Activity
Integrin Binding
Protein Binding
Peptide Disulfide Oxidoreductase Activity
Enzyme Binding
Protein Heterodimerization Activity
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Protein Folding
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Chylomicron Assembly
Very-low-density Lipoprotein Particle Assembly
Response To Endoplasmic Reticulum Stress
Interleukin-12-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Cell Redox Homeostasis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Viral Entry Into Host Cell
Oxidation-reduction Process
Cellular Response To Hypoxia
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Blood Coagulation
Visual Perception
Sensory Perception Of Sound
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Corticosteroid
Response To Estradiol
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Tooth Eruption
Positive Regulation Of Transcription, DNA-templated
Embryonic Skeletal System Development
Regulation Of Immune Response
Leukocyte Migration
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Fluoride
Pathways
Collagen biosynthesis and modifying enzymes
Detoxification of Reactive Oxygen Species
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Hedgehog ligand biogenesis
VLDL assembly
Post-translational protein phosphorylation
Chylomicron assembly
Interleukin-12 signaling
Interleukin-23 signaling
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Drugs
Zinc
Ribostamycin
Copper
Collagenase clostridium histolyticum
Halofuginone
Diseases
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
Osteogenesis imperfecta
GWAS
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Response to taxane treatment (docetaxel) (
23006423
)
Interacting Genes
22 interacting genes:
CD1D
COL10A1
COL1A1
COL1A2
CSNK2A2
EIF2S1
ERO1A
ERO1B
ESR1
FEZ1
HNRNPD
ITGB3
LGALS9
LINC00839
P4HA2
P4HA3
PRNP
PTN
TG
UBQLN1
VWF
YWHAG
38 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
THBS1
TMPRSS6
TXN
UBC
VWF
Entrez ID
5034
1277
HPRD ID
07181
00362
Ensembl ID
ENSG00000185624
ENSG00000108821
Uniprot IDs
A0A024R8S5
P07237
P02452
PDB IDs
1BJX
1MEK
1X5C
2BJX
2K18
3BJ5
3UEM
4EKZ
4EL1
4JU5
6I7S
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?