AEBP2 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 16431907)
45

Data Source:
BioGRID (pull down)

		AEBP2	H1-1
Description		AE binding protein 2	H1.1 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm ESC/E(Z) Complex	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Cell Surface Vesicle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Metal Ion Binding	Double-stranded DNA Binding Protein Binding Heparin Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic	Nucleosome Assembly Regulation Of Transcription, DNA-templated Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways		PRC2 methylates histones and DNA PKMTs methylate histone lysines	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		11 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12 THAP1	50 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		121536	3024
HPRD ID		16477	00820
Ensembl ID		ENSG00000139154	ENSG00000124610
Uniprot IDs		Q6ZN18	Q02539
PDB IDs		5WAI 5Y0U 5Y1U 6C23 6C24
Enriched GO Terms of Interacting Partners?
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