CLTB and PQBP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		CLTB	PQBP1
Description		clathrin light chain B	polyglutamine binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Cytoplasmic Component	Nucleus Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Neuronal Ribonucleoprotein Granule
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Intracellular Protein Transport Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Transcription, DNA-templated Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	mRNA Splicing - Major Pathway
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Non-syndromic X-linked mental retardation
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		7 interacting genes: CALM1 CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R PQBP1	24 interacting genes: APBB1 APP AQR ATXN1 CLTB EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Entrez ID		1212	10084
HPRD ID		00352	02354
Ensembl ID		ENSG00000175416	ENSG00000102103
Uniprot IDs		A0A024R7S3 P09497	A0A0S2Z4V5 O60828
PDB IDs			4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?
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