EXOSC6 and GSE1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		EXOSC6	GSE1
Description		exosome component 6	Gse1 coiled-coil protein
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding Exoribonuclease Activity	Protein Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Cobalt levels ( 26025379) Platelet count ( 29403010 27863252) Platelet distribution width ( 27863252) Triglyceride levels x loop diuretics use interaction ( 31806883) Triglycerides ( 30275531)
Interacting Genes		37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MPP6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	18 interacting genes: C1orf94 CDC5L CEP63 CFAP206 DGCR6 EXOSC6 GOLGA2 NUDT18 RALBP1 RBM48 RBPMS RCOR3 RUNX1T1 SRPK2 TEKT4 TNIK TRIP6 XRCC6
Entrez ID		118460	23199
HPRD ID		12107	11066
Ensembl ID		ENSG00000223496	ENSG00000131149
Uniprot IDs		Q5RKV6	Q14687
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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