CLCN3 and GOPC

Number of citations of the paper that reports this interaction (PubMedID 9843494)
107

Data Source:
HPRD (in vitro, in vivo)

		CLCN3	GOPC
Description		chloride voltage-gated channel 3	golgi associated PDZ and coiled-coil motif containing
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cell Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Specific Granule Intracellular Membrane-bounded Organelle Phagocytic Vesicle	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Cell Junction Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Solute:proton Antiporter Activity PDZ Domain Binding Chloride Ion Binding Volume-sensitive Chloride Channel Activity	Frizzled Binding Protein Binding Protein C-terminus Binding GTPase Regulator Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Regulation Of PH Negative Regulation Of Cell Volume Endosomal Lumen Acidification Chloride Transmembrane Transport Proton Transmembrane Transport	ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Spermatid Nucleus Differentiation Negative Regulation Of Anion Channel Activity Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Regulation Of Catalytic Activity Negative Regulation Of Protein Localization To Cell Surface
Pathways		Stimuli-sensing channels	RHO GTPases regulate CFTR trafficking
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)	Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Facial emotion recognition (fearful faces) ( 28608620) Night sleep phenotypes ( 27126917)
Interacting Genes		6 interacting genes: CFTR DNAJC5 GOPC HSPB1 PDZK1 SLC9A3R1	60 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CD300C CDKN2C CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 PARK7 PID1 PWWP3A RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SPATA8 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZNF564 ZNF581 ZNF587 ZSCAN1
Entrez ID		1182	57120
HPRD ID		02785	06024
Ensembl ID		ENSG00000109572	ENSG00000047932
Uniprot IDs		B3KXK0 P51790	Q9HD26
PDB IDs			2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7
Enriched GO Terms of Interacting Partners?
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