GOPC and STARD3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GOPC	STARD3
Description		golgi associated PDZ and coiled-coil motif containing	StAR related lipid transfer domain containing 3
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Cell Junction Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex	Cell Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Organelle Membrane Contact Site
	Molecular Function	Frizzled Binding Protein Binding Protein C-terminus Binding GTPase Regulator Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding	Protein Binding Cholesterol Binding Protein Homodimerization Activity Intermembrane Cholesterol Transfer Activity
	Biological Process	ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Spermatid Nucleus Differentiation Negative Regulation Of Anion Channel Activity Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Regulation Of Catalytic Activity Negative Regulation Of Protein Localization To Cell Surface	Lipid Metabolic Process C21-steroid Hormone Biosynthetic Process Progesterone Biosynthetic Process Mitochondrial Transport Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Vesicle Tethering To Endoplasmic Reticulum
Pathways		RHO GTPases regulate CFTR trafficking	Pregnenolone biosynthesis
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Facial emotion recognition (fearful faces) ( 28608620) Night sleep phenotypes ( 27126917)	Alcohol consumption ( 31358974) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 30108155) Ulcerative colitis ( 20228799)
Interacting Genes		60 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CD300C CDKN2C CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 PARK7 PID1 PWWP3A RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SPATA8 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZNF564 ZNF581 ZNF587 ZSCAN1	4 interacting genes: CREB3 DAPK1 GOPC LMNA
Entrez ID		57120	10948
HPRD ID		06024	06132
Ensembl ID		ENSG00000047932	ENSG00000131748
Uniprot IDs		Q9HD26	Q14849
PDB IDs		2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7	1EM2 2I92 5I9J
Enriched GO Terms of Interacting Partners?
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