ADCYAP1 and CPAMD8

Number of citations of the paper that reports this interaction (PubMedID 1335692)
6

Data Source:
BioGRID (unspecified method)

		ADCYAP1	CPAMD8
Description		adenylate cyclase activating polypeptide 1	C3 and PZP like alpha-2-macroglobulin domain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Neuron Projection Terminal Bouton Perikaryon	Extracellular Space Plasma Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Insulin Secretion Neuron Projection Development Positive Regulation Of Interleukin-6 Production Regulation Of Protein Localization Negative Regulation Of GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II ATP Metabolic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Somatostatin Secretion Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Cold-induced Thermogenesis	Eye Development Negative Regulation Of Endopeptidase Activity
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Brain lesion load ( 19010793) Crohn's disease ( 22412388) Height ( 28552196)
Interacting Genes		8 interacting genes: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	3 interacting genes: ADCYAP1 DPP4 SCTR
Entrez ID		116	27151
HPRD ID		02369	09892
Ensembl ID		ENSG00000141433	ENSG00000160111
Uniprot IDs		B7Z222 P18509	A0A494C0S9
PDB IDs		1GEA 2D2P 2JOD
Enriched GO Terms of Interacting Partners?
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