PTP4A3 and FNTB

Number of citations of the paper that reports this interaction (PubMedID 10747914)
42

Data Source:
HPRD (in vitro)

		PTP4A3	FNTB
Description		protein tyrosine phosphatase 4A3	farnesyltransferase, CAAX box, beta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Plasma Membrane	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Prenylated Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Notch Signaling Pathway Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Vascular Permeability Endothelial Cell Migration Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Establishment Of Protein Localization Cellular Response To Leukemia Inhibitory Factor	Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway
Pathways			Inactivation, recovery and regulation of the phototransduction cascade
Drugs			AZD3409 Tipifarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Diastolic blood pressure ( 27841878) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 27841878)	Blood trace element (Zn levels) ( 23720494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23222517)
Interacting Genes		4 interacting genes: CDKN2A FNTA FNTB FZR1	9 interacting genes: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2
Entrez ID		11156	2342
HPRD ID		05922	00608
Ensembl ID		ENSG00000184489	ENSG00000257365
Uniprot IDs		O75365	A0A384MEJ5 P49356
PDB IDs		1R6H 1V3A 2MBC 5TSR	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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