ADCY5 and GNAS

Number of citations of the paper that reports this interaction (PubMedID 9268375)
43

Data Source:
HPRD (in vitro)

		ADCY5	GNAS
Description		adenylate cyclase 5	GNAS complex locus
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Intermediate Filament Cytoskeleton	Cytosol Heterotrimeric G-protein Complex Membrane Apical Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Scaffold Protein Binding	G Protein-coupled Receptor Binding GTPase Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Activator Activity G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Adenosine Receptor Signaling Pathway Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotory Behavior Activation Of Protein Kinase A Activity Neuromuscular Process Controlling Balance Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Forskolin	Tissue Homeostasis Endochondral Ossification Energy Reserve Metabolic Process DNA Methylation Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Post-embryonic Body Morphogenesis Positive Regulation Of Catalytic Activity Skin Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Developmental Growth Embryonic Cranial Skeleton Morphogenesis Cartilage Development Bone Development Platelet Aggregation Genetic Imprinting Positive Regulation Of Cold-induced Thermogenesis Regulation Of Parathyroid Hormone Secretion
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases			Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy Pseudohypoparathyroidism Progressive osseous heteroplasia (POH)
GWAS		Birth weight ( 23202124 31043758 27680694 20372150) Body mass index ( 25673413) Chronic kidney disease ( 26420894) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Gestational age at birth (maternal effect) ( 28877031) Glycated hemoglobin levels ( 28898252) Glycemic traits (pleiotropy) ( 31021400) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function ( 20081858) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lymphocyte counts ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 27863252) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Total cholesterol levels ( 29083408) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 22693455 29358691 30297969 28254843 26818947 28869590)	Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 21909115 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) Height ( 31562340) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		7 interacting genes: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2	35 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CHEK2 CRHR1 EGFR GCGR GLP1R GNB1 GNGT1 HTR6 LHB LHCGR MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		111	2778
HPRD ID		08973	00761
Ensembl ID		ENSG00000173175	ENSG00000087460
Uniprot IDs		A0A384P5Q5 B3KWA8 B7Z2C7 O95622	A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWF2
PDB IDs			5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6NI3 6NIY
Enriched GO Terms of Interacting Partners?
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