ADCY5

Description		adenylate cyclase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Scaffold Protein Binding
	Biological Process	Adenosine Receptor Signaling Pathway Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotory Behavior Activation Of Protein Kinase A Activity Neuromuscular Process Controlling Balance Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases
GWAS		Birth weight ( 23202124 31043758 27680694 20372150) Body mass index ( 25673413) Chronic kidney disease ( 26420894) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Gestational age at birth (maternal effect) ( 28877031) Glycated hemoglobin levels ( 28898252) Glycemic traits (pleiotropy) ( 31021400) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function ( 20081858) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lymphocyte counts ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 27863252) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Total cholesterol levels ( 29083408) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 22693455 29358691 30297969 28254843 26818947 28869590)
Interacting Genes		7 interacting genes: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2
Entrez ID		111
HPRD ID		08973
Ensembl ID		ENSG00000173175
Uniprot IDs		A0A384P5Q5 B3KWA8 B7Z2C7 O95622
PDB IDs
Enriched GO Terms of Interacting Partners?
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