CHD4 and IKZF4

Number of citations of the paper that reports this interaction (PubMedID 12015313)
24

Data Source:
HPRD (in vivo)

		CHD4	IKZF4
Description		chromodomain helicase DNA binding protein 4	IKAROS family zinc finger 4
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Myopia (pathological) ( 23049088)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 21804548 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)
Interacting Genes		19 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 RNF8 RORC SMARCA4 SUMO2 TRIM27 TWIST1 UBE2I XRN1	12 interacting genes: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B
Entrez ID		1108	64375
HPRD ID		04472	05874
Ensembl ID		ENSG00000111642	ENSG00000123411
Uniprot IDs		F5GWX5 Q14839	Q9H2S9
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG	2MA7
Enriched GO Terms of Interacting Partners?
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